ProfhEX

AI-based platform for small molecules polypharmacology profiling

Drug polypharmacology is crucial to the success or failure of candidate compounds in drug discovery. Understanding how a compound interacts with various targets helps predict its therapeutic potential and minimize risks early in development.

ProfhEX an AI-powered platform, profiles small molecules across 693 relevant targets, enabling polypharmacology analysis, liability profiling (off-targets), and drug repurposing.

Users can upload molecules in SMILES format to receive downloadable activity profiles and summary reports. All models are OECD-compliant and accessible in the Models section. Available models can be browsed in the Models section.

AI

Deep Learning

Analysis

Due to security restrictions, SAS Viya reports are only viewable in the Chrome web browser. However, results can still be downloaded using other browsers. To use this tool on Edge and Firefox, you must allow cross-site tracking cookies or add the site name to the tracking prevention exceptions in your privacy settings. Chrome does not require these adjustments.

Protein Families













Activity Type




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SAS

Available models can be selected in the drop-down list or browsed in the treemap visualization. The report displays key model quality information:

  • Training set size and pK property distribution
  • External validation performance
  • Internal validation evaluation

* To use this tool on Edge and Firefox you must allow cross-site tracking cookies or add the site name to the tracking prevention exceptions in the privacy settings; on Chrome you do not need to.

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